Publications

2024

Wu CW, Tabarraei H. CCR4-NOT complex in stress resistance and longevity in C. elegans. Aging (Albany NY). 16(10):8400-9305

Waddell BM, Wu CW (2024). A role for the C. elegans Argonaute protein CSR-1isoform in small nuclear RNA 3' processing. PLoS Genet. 20(5): e1011284. 

Abaham E, Athapaththu AMGK, Atanasova KR, Chen QY, Corcoran TJ, Piloto K, Wu CW, Ratnayake R, Luesch H, Choe KP (2024). Chemical genetics in C. elegans identifies anticancer mycotoxins chaetocin and chetomin as potent inducers of a nuclear metal homeostasis response. ACS Chem Biol. 19(5):1180–1193

2023

Tabarraei H, Waddell BM, Wu CW (2023). Investigation of PAL-1 requirement in C. elegans physiology using the auxin-inducible degradation system. microPublication Biology. 10.17912/micropub.biology.001057

Huynh D, Wu CW (2023). Identification of pararosaniline as a modifier of RNA splicing in Caenorhabditis elegans. Genes|Genomes|Genetics. jkad241.doi.org/10.1093/g3journal/jkad241

Tabarraei H, Waddell BM, Raymond K, Murray SM, Wang Y, Choe KP, Wu CW. (2023). CCR4-NOT subunit CCF-1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans. Aging Cell. e13795. doi: 10.1111/acel.13795

2022

Huynh D, Wu CW (2022). High-throughput identification of oxidative stress-inducing environmental chemicals in the C. elegans system. Free Radic Biol Med . 191:59-65.

Chomyshen SC, Tabarraei H, Wu CW (2022). Translational suppression via IFG-1/eIF4G inhibits stress-induced RNA alternative splicing in Caenorhabditis elegans. Genetics. 221(3):iyac075.

Comfort JJ, Chomyshen, SC, Waddell BM, Tabarraei H, Wu CW (2022). Molecular characterization of ethyl carbamate toxicity in Caenorhabditis elegans. Toxicology Rep. 9:619-627.

2021

Wu CW, Storey KB (2021). mTOR signaling in Metabolic Stress Adaptation. Biomolecules 11(5),681.

2020

Murray SM, Waddell BM, Wu CW (2020). Neuron-specific toxicity of chronic acrylamide exposure in C. elegans. Neurotoxicol Teratol. 77:106848.

Wu CW, Tessier SN, Storey KB (2020). Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis. Comp Biochem Physiol B Biochem Mol Biol. 246-247:110461.

Al-attar R, Wu CW, Biggar KK, Storey KB (2020). Carb-Loading: Freeze-Induced Activation of the Glucose-Responsive ChREBP Transcriptional Network in Wood Frogs. Physiol Biochem Zool. 93(1):49-91.

2019

Wu CW, Wimberly K, Pietra A, Dodd W, Atlas MB, Choe KP (2019). RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress. BMC Biol. 17(1):56

Biggar KB, Luu BE, Wu CW, Pifferi F, Perret M, Storey KB. (2019). Identification of novel and conserved microRNA and their expression in the gray mouse lemur, Microcebus murinus, a primate capable of daily torpor. Gene. 677:332-339 

Tessier SN, Wu CW, Storey KB. (2019). Molecular control of protein synthesis, glucose metabolism, and apoptosis in the brain of hibernating thirteen-lined ground squirrels. Biochem Cell Biol. 97(5)536-544 

Logan SM, Wu CW, Storey KB. (2019). The squirrel with the lagging eIF2: Global suppression of protein synthesis during torpor. Comp Biochem Physiol A Mol Integr Physiol .227: 161-171.

2018

Wu CW, Tessier SN, Storey KB. (2018) Stress induced antioxidant defense and protein chaperone response in the freeze-tolerant wood frog Rana sylvatica. Cell Stress Chaperones. 23(6):1205-1217.

Dodd W, Tang L, Lone JC, Wimberly K, Wu CW, Consalvo C, Wright J, Pujols N, Choe KP.  (2018). A Damaged Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses in Caenorhabditis elegans. Genetics. 208(4):1467-1482. Issue Highlight.

Wu CW and Storey KB (2018). Regulation of Smad mediated microRNA transcriptional response in ground squirrels during hibernation. Mol Cell Biochem. 439(1-2):151-161.

2017

Wu CW and Storey KB (2017). Hibernation and Aging: Molecular mechanisms of mammalian hypometabolism, and its links to longevity. (ISBN 9781138196971 Invited book chapter in “Aging: Exploring a Complex Phenomenon”, CRC Press)

Wu CW, Wang Y, Choe KP. (2017). F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans. Genetics. 206(2):859-871.

Wu CW, Tessier SN, Storey KB (2017). Regulation of the insulin-Akt signaling pathway and glycolysis during dehydration stress in the African clawed frog Xenopus laevis. Biochem Cell Biol. 95(6):663-671.

2016

Wu CW, Deonarine A, Przybysz AJ, Strange K, Choe KP (2016). The Skp1 homologs SKR-1/2 are required for the Caenorhabditis elegans SKN-1 antioxidant/detoxification response independently of p38 MAPK. PLoS Genet. 12(10):e1006361.

Wu CW, Biggar KK, Luu BE, Szereszewski KE, Storey KB (2016). Analysis of microRNA expression during the torpor-arousal cycle of a mammalian hibernator, the 13-lined ground squirrel. Physiol Genomics. 48(6):388-396.

Luu BE, Biggar KK, Wu CW, Storey KB (2016). Torpor-responsive expression of species-specific microRNA in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. FEBS Lett. 590(20):3574-3582.

Wu CW, Storey KB (2016). Life in the cold: links between mammalian hibernation and longevity. BioMol Concepts. 7(1):41-52.

2015

Wu CW, Bell RA, Storey KB (2015). Post-translational regulation of PTEN catalytic function and protein stability in the hibernating 13-lined ground squirrel. Biochim Biophys Acta. 1850(11):2196-202.

Hefler J*, Wu CW*, Storey KB (2015) Transcriptional activation of p53 during cold induced torpor of the 13-lined ground squirrel Ictidomys tridecemlineatus. Biochem Res Int. 731595:1-11.

Wu CW*, Biggar KK*, Tessier ST, Zhang J, Pifferi F, Perret M, Storey KB (2015). Induction of Antioxidant and Heat Shock Protein Responses During Torpor in the Mouse Lemur, Microcebus murinus. Genomics, Proteomics and Bioinformatics. 13(2):119-126.

Biggar KK*, Wu CW*, Tessier SN, Zhang J, Pifferi F, Perret M, Storey KB (2015). Primate torpor: Regulation of stress-activated protein kinases during daily torpor in the grey mouse lemur, Microcebus murinus. Genomics, Proteomics and Bioinformatics. 13(2):81-90.

Tessier SN, Zhang J, Biggar KK, Wu CW, Pifferi F, Perret M, Storey, KB (2015). Regulation of the PI3K/AKT Pathway and Fuel Utilization During Primate Torpor in the Grey Mouse Lemur, Microcebus murinus. Genomics, Proteomics and Bioinformatics. 13(2):91-102.

Biggar KK*, Wu CW*, Tessier SN, Zhang J, Pifferi F, Perret M, Storey KB (2015). Modulation of gene expression in key survival pathways during daily torpor in the grey mouse lemur, Microcebus murinus. Genomics, Proteomics and Bioinformatics. 13(2):111-118.  

Zhang J, Tessier SN, Biggar KK, Wu CW, Pifferi F, Perret M, Storey KB (2015). Regulation of Torpor in the Grey Mouse Lemur: Transcriptional and Translational Controls and Role of AMPK Signaling. Genomics, Proteomics and Bioinformatics. 13(2):103-110. 

2014

Biggar KK*, Wu CW*, Storey KB (2014). High-throughput amplification of mature microRNA in uncharacterized animal models using polyadenylated RNA and stem-loop RT-PCR. Anal Biochem. 462:32-34. 

Wu CW and Storey KB (2014). FoxO3a-mediated activation of stress responsive genes during early torpor in a mammalian hibernator. Mol Cell Biochem. 390(1-2):185-195.

Tessier SN, Audas TE, Wu CW, Lee S, Storey KB (2014). The involvement of mRNA processing factors TIA-1, TIAR, and PABP-1 during mammalian hibernation. Cell Stress Chaperones. 19(6): 813-825.

Wu CW, Biggar KK, Storey KB (2014). Expression Profiling and Structural Characterization of MicroRNAs in Adipose Tissues of Hibernating Ground Squirrels. Genomics Proteomics Bioinformatics. 12(6):284-291.

2013

Wu CW, Biggar KK, and Storey KB (2013). Dehydration mediated microRNA response in the African clawed frog Xenopus laevis. Gene. 592(2):269-275.

Wu CW, Reardon AJ, and Storey KB (2013). Effects of hibernation on regulation of mammalian protein phosphatase type-2-A. Cryobiology. 3(66):267-274.

Storey KB and Wu CW (2013). Stress response and adaptation: a new molecular toolkit for the 21st century. Comp Biochem Physiol A Mol Integr Physiol. 165(4):417-428.

Wu CW, Biggar KK, and Storey KB (2013). Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance. Braz J Med Biol Res. 46(1):1-13.

2012

Wu CW and Storey KB (2012). Regulation of the mTOR signaling network in hibernating thirteen-lined ground squirrels. J Exp Biol. 215(Pt 10):1720-1727.

Wu CW and Storey KB (2012). Pattern of cellular quiescence over the hibernation cycle in liver of thirteen-lined ground squirrels. Cell Cycle. 11(9):1714-1726.